1 In 1899, the German pharmaceutical company Friedrich Bayer and Co. It has served as the primary ingredient in analgesic, antipyretic, and anti-inflammatory medications since the fifth century bc in ancient Greece.Ĭharles Frédéric Gerhardt, a French chemist, synthesized an unstable, impure form of ASA in 1853. Salicin, a compound first extracted from the bark of willow plant species ( Salix), is the precursor of synthetically derived acetylsalicylic acid (ASA), or aspirin.
Salicylate and its derivatives are ubiquitous agents found in over-the-counter and prescription medications. Key words: salicylate, acetylsalicylic acid, aspirin, salicylate poisoning, salicylate toxicity, salicylism, methyl salicylate, ototoxicity, tinnitus, hyperventilation, hyperpnea, respiratory alkalosis, metabolic acidosis, Krebs cycle, oxidative phosphorylation, hyperthermia, seizures, anion gap, sodium bicarbonate, urine alkalinization, Done nomogram This article reviews the pathophysiology of salicylate metabolism, the clinical and diagnostic clues of an acute overdose, and the cellular response of salicylate poisoning on various organ systems, as well as differential diagnoses and treatment approaches to toxicity in children. Despite a decline in popularity, this chemical compound’s ubiquity and accessibility results in it being frequently implicated in childhood drug poisonings. Abstract: Salicylate and its derivatives are commonly found worldwide in common medications used to treat pain, fever, and inflammation.
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